This whole area is east of the Vltava river. From north to south the main destinations are commented.
North of Josefov, across the river, there is a large park located in the Letna hill. In good weather it can be a very nice place to relax or from where contemplate the city, but without it it can be unpleasant and somewhat seedy. There is a giant working metronome presiding (23 meters).
It is the Jewish quarter of the city since the 10th century, architecture is similar to that in Stare Mesto and Nove Mesto. There are many synagogues, a Jewish cemetery and a statue of Kafka.
The main and most famous area of the city. The star is Staromestska Square, world famous for the church of Tyn and the astronomical clock. There are many other streets with excellent architecture. It is also the core for restaurants and shopping.
Personally, I found interesting the Alphonse Mucha Museum, because it cannot be seen anywhere else, a Czech artist of the late 19th century, known for his art nouveau paintings, drawings and illustrations. Open daily from 10 am to 6 pm, admission 240 CZK.
In Nove Mesto there are no statues, museums, bridges, nor important churches, but there is a building that has become world famous since its construction in 1996, Frank Gehry’s Dancing House or Fred & Ginger.
It is also my favorite neighborhood in terms of architecture, especially the buildings overlooking the Vltava River.
This area is really worthy it if you have more than one day in the city. It is far from the center, about 45 minutes walking south; Vyton tram station is the closest by public transport. It is a 10th century citadel, perched on a hill.
The Neo-Gothic church of St. Peter and St. Paul is one of the most prominent buildings, and the interior is impressive.
It is also well known the Slavin National Cemetery, where 600 Czech personalities rest.